Towards the Directed Evolution of Artificial Metalloenzymes
نویسندگان
چکیده
منابع مشابه
5. Directed evolution of artificial metalloenzymes: bridging synthetic chemistry and biology
Directed evolution is a powerful algorithm for engineering proteins to have novel and useful properties. However, we do not yet fully understand the characteristics of an evolvable system. In this chapter, we present examples where directed evolution has been used to enhance the performance of metalloenzymes, focusing first on ‘classical’ cases such as improving enzyme stability or expanding th...
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Biological development is a complex process that mediates between genotypes, to which mutations occur, and phenotypes, on which selection acts. Properties of development can therefore have considerable impact on evolution. However, in many existing simulation models of development, the developmental process itself is difficult to recover and/or analyse. We have previously introduced a model of ...
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Catalysis is the most efficient strategy for the preparation of enantiopure products. Homogeneous and enzymatic catalyses are in many respects complementary in terms of substrate and reaction scope, operating conditions, enantioselection mechanism, etc. In terms of performance optimization, directed evolution methodologies outperform combinatorial ligand libraries. With the aim of combining the...
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ژورنال
عنوان ژورنال: CHIMIA International Journal for Chemistry
سال: 2021
ISSN: 0009-4293
DOI: 10.2533/chimia.2021.257